2024 Redox-dependent gating of vdac by mitoneet

Redox-dependent gating of vdac by mitoneet

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August undefined, 2024

Web1. jan 2014 · Mitochondrial VDAC1 was purified from rat brain as per the standard procedure. 31, 32 Briefly, the brain of euthanized Wistar rats was removed and placed in solution A [250 mM Sucrose, 0.1 mM... WebWe find that the redox-sensitive [2Fe-2S] cluster protein mitoNEET gates VDAC1 when mitoNEET is oxidized. Addition of the VDAC inhibitor 4,4′-diisothiocyanatostilbene-2,2′- …

Redox-dependent gating of VDAC by mitoNEET - NASA/ADS

WebThe functioning of mitochondria and their biogenesis are largely based on the proper function of the mitochondrial outer membrane channels, which selectively recognise and import proteins but also transport a wide range of other molecules, including metabolites, inorganic ions and nucleic acids. To date, nine channels have been identified in the … Web@article{Lipper2024RedoxdependentGO, title={Redox-dependent gating of VDAC by mitoNEET}, author={Colin H. Lipper and Jason T. Stofleth and Fang Bai and Yang Sung … thin roasted potatoes

Sci-Hub Redox-dependent gating of VDAC by mitoNEET.

Web20. aug 2024 · MitoNEET is a mitochondrial outer membrane protein that hosts a redox active [2Fe-2S] cluster in the C-terminal cytosolic domain. Increasing evidence has shown that mitoNEET has an essential role in regulating energy metabolism in human cells. Previously, we reported that the [2Fe-2S] clusters in mitoNEET can be reduced by the … Web11. sep 2024 · Human mitoNEET (mNT) is the first identified Fe–S protein of the mammalian outer mitochondrial membrane. Recently, we demonstrated the involvement of mNT in a specific cytosolic pathway dedicated to the reactivation of oxidatively damaged cytosolic aconitase by cluster transfer. WebVDAC (voltage-dependent anion selective channel) proteins, also known as mitochondrial porins, are the most abundant proteins of the outer mitochondrial membrane (OMM), where they play a vital role in various cellular processes, in the regulation of metabolism, and in survival pathways. There is increasing consensus about their function as a cellular hub, … thin robes for women

Redox-dependent gating of VDAC by mitoNEET - JSTOR

WebmitoNEET-dependent mitochondrial iron accumulation in situ. We find that the DIDS inhibitor does not alter the redox state of MitoNEET. Taken together, our data indicate that … WebThe Voltage-Dependent Anion-selective Channel (VDAC) is the pore-forming protein of mitochondrial outer membrane, allowing metabolites and ions exchanges. In … thin roadWeb10. okt 2024 · We find that the redox-sensitive [2Fe-2S] cluster protein mitoNEET gates VDAC1 when mitoNEET is oxidized. Addition of the VDAC inhibitor 4,4′ … thin rock tile

"WebIn the outer mitochondrial membrane, the voltage-dependent anion channel 1 (VDAC1) functions in cellular Ca2+ homeostasis by mediating the transport of Ca2+ in and out of mitochondria. VDAC1 is... " - Redox-dependent gating of vdac by mitoneet

Redox-dependent gating of vdac by mitoneet

WebThis work demonstrates that the outer mitochondrial-anchored [2Fe-2S] mitoNEET is able to bind within the central cavity of the voltage-dependent anion channel (VDAC) and regulate its gating in a redox-dependent manner. These findings have implications for ferroptosis, apoptosis, and iron metabolism by linking VDAC function, mitoNEET, and the redox … WebProceedings of the National Academy of Sciences of the United States of America (ISSN: 0027-8424, 1091-6490)

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Web1. okt 2024 · Redox-dependent gating of VDAC by mitoNEET.: MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation of iron and reactive oxyge It is a key player in multiple human maladies including diabetes, cancer, neurodegeneration, and Parkinson's diseases. Webthe voltage-dependent anion channel (VDAC) and regulate its gating in a redox-dependent manner. These findings have im-plications for ferroptosis, apoptosis, and iron metabolism …

Web16. sep 2024 · MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation of iron and reactive oxygen species (ROS) homeostasis. It is a key player in … Web2. sep 2010 · MitoNEET is a newly discovered mitochondrial protein and a target of the TZD class of antidiabetes drugs. MitoNEET is homodimeric with each protomer binding a [2Fe-2S] center through a rare 3-Cys and 1-His coordination geometry. Both the fold and the coordination of the [2Fe-2S] centers suggest that it could have novel properties compared …

Web1. okt 2024 · Redox-dependent gating of VDAC by mitoNEET.: MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation of iron and reactive …

WebIsoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells (2024) …

WebSci-Hub Redox-dependent gating of VDAC by mitoNEET. Proceedings of the National Academy of Sciences, 202408271 10.1073/pnas.1908271116. sci. hub. to open science. … thin robot vacuum cleanerWeb1. nov 2009 · Here we have observed for the first time that two members of the TZD drug family similarly affect mitoNEET redox chemistry: pK ox increases by ~2 units, resulting in a lowering of E m,7 by > 100mV. Thus, drug binding has a fundamental impact on the redox activity of mitoNEET. ... Redox-dependent gating of VDAC by mitoNEET. Lipper CH, … thin rockWebSignificance This work demonstrates that the outer mitochondrial-anchored [2Fe-2S] mitoNEET is able to bind within the central cavity of the voltage-dependent anion channel … thin rocker switchWebWe find that the redox-sensitive [2Fe-2S] cluster protein mitoNEET gates VDAC1 when mitoNEET is oxidized. Addition of the VDAC inhibitor 4,4′-diisothiocyanatostilbene-2,2′-disulfonate (DIDS) prevents both mitoNEET binding in vitro and mitoNEET-dependent mitochondrial iron accumulation in situ. thin rock veneerWebWe find that the redox-sensitive [2Fe-2S] cluster protein mitoNEET gates VDAC1 when mitoNEET is oxidized. Addition of the VDAC inhibitor 4,4′-diisothiocyanatostilbene-2,2′ … thin rocker seat cushionsWeb16. sep 2024 · Redox-Dependent Gating of VDAC by mitoNEET Proceedings of the National Academy of Sciences of the United States of America - United States doi … thin robot vacuumWeb16. sep 2024 · Europe PMC is an archive of life sciences journal literature. thin rock climbing socks