WebIn CPIC’s Recommended Dosing of Simvastatin Based on SLCO1B1 Phenotype, all haplotypes conferring increased risk of simvastatin myopathy (*5, *15, and *17) contain the SLCO1B1 521C polymorphism. 26 CPIC’s SLCO1B1-based prescribing guidance for simvastatin is a commonly cited example of formal guidance regarding the … WebMar 13, 2024 · In contrast, the Clinical Pharmacogenetics Implementation Consortium (CPIC) published their guideline on simvastatin, but not on atorvastatin. In this work, we aimed to demonstrate the effect of SLCO1B1 phenotype and other variants (e.g., in CYP3A4/5, UGT enzymes or SLC transporters) on atorvastatin pharmacokinetics.
National Center for Biotechnology Information
WebSep 1, 2024 · Official guidance for interpreting simvastatin-SLCO1B1 drug-genotype tests is provided in CPIC's table, ‘recommended dosing of simvastatin based on SLCO1B1 phenotype’ . For this analysis, simvastatin- SLCO1B1 test results were considered potentially actionable when the patient's SLCO1B1 genetic status was consistent with … WebFeb 13, 2024 · The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for SLCO1B1, ABCG2, and CYP2C9 and statin-associated musculoskeletal symptoms … CPIC assigns CPIC levels to genes/drugs with (1) PharmGKB Clinical Annotation … people in west virginia
The Clinical Pharmacogenomics Implementation Consortium: CPIC …
WebFeb 12, 2024 · Genetic variation in each of these genes alters systemic exposure to statins (i.e., simvastatin, rosuvastatin, pravastatin, pitavastatin, atorvastatin, fluvastatin, lovastatin), which can increase the risk for SAMS. ... This document replaces the 2012 and 2014 Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for SLCO1B1 and ... WebJul 1, 2012 · A non‐synonymous coding single‐nucleotide polymorphism (SNP) in SLCO1B1 markedly increases systemic exposure to simvastatin and the risk of muscle toxicity and this guideline explores the relationship between rs4149056 and clinical outcome for all statins. Cholesterol reduction from statin therapy has been one of the greatest public … WebMay 23, 2012 · The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy May 2012 Clinical Pharmacology & Therapeutics 92(1):112-7 tofte bluefin bay resort