Cep164 ttbk2
WebMar 26, 2024 · Here, we present a detailed biochemical, structural, and functional analysis of the CEP164-TTBK2 complex and demonstrate how it is compromised by two ciliopathic mutations in CEP164. Moreover, we also provide insights into how binding to CEP164 is coordinated with TTBK2 activities. Together, our data deepen our understanding of a … WebAug 27, 2024 · Since CEP164 was required for TTBK2 to associate with DAs (Čajánek and Nigg, 2014; Oda et al., 2014), we also tested the involvement of CEP164 in the …
Cep164 ttbk2
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WebMar 25, 2024 · Here, we present a detailed biochemical, structural, and functional analysis of the CEP164-TTBK2 complex and demonstrate how it is compromised by two ciliopathic mutations in CEP164. Moreover, we also provide insights into how binding to CEP164 is coordinated with TTBK2 activities. Together, our data deepen our understanding of a … WebApr 1, 2024 · Here, we present a detailed biochemical, structural, and functional analysis of the CEP164-TTBK2 complex and demonstrate how it is compromised by two ciliopathic …
WebSep 8, 2024 · CEP164-TTBK2 interaction facilitates TTBK2-mediated phosphorylation of both CEP83 [8,9] and M-Phase Phosphoprotein 9 (MPP9) at the distal end of the mother centriole . MPP9 and the … WebJan 27, 2014 · The distal appendages of the mother centriole, also known as transition fibers of the cilium, are protein complexes comprising at least five components (Ccdc41/Cep83, Cep89/Cep123, Sclt1, Fbf1, and Cep164) ().Distal appendages are critical for the recruitment of Tau tubulin kinase 2 (Ttbk2), which appears to play a critical role in …
WebMar 1, 2024 · This region, as an example, binds Tau tubulin kinase 2 (TTBK2) 9, an enzyme critical to the initiation of ciliogenesis 31. Thus, broad distribution of Cep164 N-termini could act as a platform for ... WebJan 10, 2024 · Our analysis highlights two protein modules, CEP83-SCLT1 and CEP164-TTBK2, as critical for structural assembly of distal appendages. Functional assay revealed that CEP89 selectively functions in RAB34+ ciliary vesicle recruitment, while deletion of the integral components, CEP83-SCLT1-CEP164-TTBK2, severely compromised all four …
WebJan 6, 2024 · TTBK2 interacts through a proline-rich C-terminal region (TTBK2 1074−1085) with a predicted WW domain (CEP164 62−84) in the N-terminal part of CEP164 …
WebSep 1, 2024 · Here, we present a detailed biochemical, structural, and functional analysis of the CEP164-TTBK2 complex and demonstrate how it is compromised by two ciliopathic mutations in CEP164. Moreover, we ... boucher waukesha gmcWebOct 1, 2014 · TTBK2 binds to CEP164 at the DAs, which is regulated by the phosphatidylinositol(4)P 5-kinase (PIPKIγ)-mediated depletion of phosphatidylinositol-4-. … boucherville weather septemberWebJun 30, 2014 · In vivo, TTBK2 triggered a pronounced Cep164 upshift, not only when coexpressed with full-length protein, but also with Cep164 N-term, M-part, or C-term fragments, demonstrating the existence of … boucher volkswagen of franklin partsWebApr 14, 2024 · Recruited by CEP164, TTBK2 colocalizes with CEP83 at the root of the centriole distal appendage 15,36,37. Phosphorylation of CEP83 by TTBK2 is essential … boucher vs walmartWebJul 13, 2015 · Knockdown/rescue experiments of TTBK2 revealed that wild-type TTBK2, but not Cep164-non-binding mutants, rescued CP110 removal and ciliogenesis in TTBK2-depleted cells. Thus, Cep164 binding of TTBK2 is critical for its function to promote CP110 removal and ciliogenesis. We also found that TTBK2 phosphorylates Cep164 and … boucher\u0027s electrical serviceWebThe connecting linkers between CEP164-NTD and the CEP164 coiled-coil domain and between the CEP164-bound TTBK2 1074−1084 region and the N-terminal TTBK2 kinase domain (PDB: 6vrf ) ( Bao et al., 2024) are drawn in an extended and open conformation. Based on disorder predictions and the paucity of predicted secondary structure … bouches auto olean nyWebKM4164B Product details. GENERAL DESCRIPTION. The KM4164B is a fully decoded NMOS Dynamic Random Access Memory organized as 65,536 one-bit words. The … bouche saint laurent boyfriend t shirt